- AMG S 63 4-matic+ (222.188) 450 kW from 2017.05
- S 300 BlueTEC Hybrid (222.004, 222.104) 150 kW from 2014.02
- S 300 BlueTEC Hybrid (222.104) 170 kW from 2014.02
- S 320 (222.162) 200 kW from 2014.05
- S 350 BlueTEC (222.032, 222.132) 190 kW from 2013.05
- S 350 BlueTEC 4-matic (222.033, 222.133) 190 kW from 2014.02
- S 350 BlueTEC 4-matic (222.133) 185 kW from 2014.02
- S 400 245 kW from 2013.09
- S 400 4-matic (222.067) 245 kW from 2014.11
- S 400 Hybrid (222.057, 222.157) 225 kW from 2013.05
- S 500 (222.082, 222.182) 335 kW from 2013.05
- S 500 320 kW from 2013.09
- S 500 4-matic (222.085, 222.185) 335 kW from 2013.05
- S 500 Hybrid (222.163) 245 kW from 2014.07
- S 500 Maybach (222.982) 335 kW from 2014.12
- S 500 Maybach 4-matic (222.985) 335 kW from 2015.04
- S 560 (222.083, 222.183) 345 kW from 2017.07
- S 560 4-matic (222.086, 222.186) 345 kW from 2017.05
- S 560 Maybach (222.983) 345 kW from 2017.07
- S 560 Maybach 4-matic (222.986) 345 kW from 2017.07
- S 600 (222.176) 390 kW from 2014.02
- S 600 Maybach (222.976) 390 kW from 2014.12
- S 63 AMG (222.077) 430 kW from 2013.05
- S 63 AMG 4-matic (222.178) 430 kW from 2013.05
- S 65 AMG (222.179) 463 kW from 2014.02
- S 650 Maybach (222.980) 463 kW from 2017.07